Enantiodivergent synthesis of the quinolizidine poison frog alkaloid 195C

Abstract Herein, we describe the enantiodivergent synthesis of the 1,4- cis -disubstituted quinolizidine alkaloid 195C . Although the stereoselectivity of the final hydrogenation reaction was low, we have proposed the first chiral total synthesis of both (−)- and (+)- 195C as an enantiodivergent process.