5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
1976
Through a controlled double-blind study in 30 hospitalized patients affected
with endogenous depression, the antidepressant action of the combination of nialamide +
l-5-HTP has been evaluated and compared with a control group which only received nialamide
(+ placebo). The patients treated with nialamide + l-5-HTP achieved a fuller recovery
than those who were treated with nialamide alone. The treatment with nialamide + l-5-HTP
proved to have a shorter delay of onset. Side effects showed no marked differences except
for the orthostatic hypotension which was less apparent in those patients treated with
nialamide + l-5-HTP.
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