Role of asymmetric dimethylarginine in rheumatological disease's cardiovascular complications

Inflammation that is an independent predictor of cardiovascular disease plays a important role in rheumatological diseases. Asymmetric dimethylarginine (ADMA), an inhibitor of endogenous nitric oxide synthase, contributes to the inflammatory syndrome. Elevated ADMA levels in many rheumatological diseases suggest that ADMA might play an important role in the rheumatological diseases and cardiovascular complication. In this review, we discuss the role of ADMA in rheumatological disease's cardiovascular complications. Key words: Arginine/ME; Rheumatic diseases/CO/ME; Immune system diseases/CO/ME; Review