placebo-controlled trial Nefazodone and imipramine in major depression: a

British Journal of Psychiatry (1994), 164, 802—805Nefazodone is a phenylpiperazine compound whichis active in several preclinical models predictive ofantidepressant potential (Eison et a!, 1990). Theantidepressant activity of nefazodone is thought tobe derived from both its 5-HT2 antagonism and itsmoderate 5-FIT reuptake inhibition, which jointly mayenhance serotonergic neurotransmission. Chronicadministration of nefazodone also results in reduced