CORRELATION BETWEEN CEREBRAL OXYGEN METABOLISM AND CEREBRAL BLOOD FLOW SIMULTANEOUSLY MEASURED BEFORE AND AFTER ACETAZOLAMIDE ADMINISTRATION

The cerebral circulation and metabolism of ten preoperative cardiac surgery patients were assessed. Alterations in regional cerebral blood flow (rCBF), measured by 123 I-N-isopropyl-p-iodo-amphetamine singlephoton emission computed tomography, and in cerebral oxygen metabolism, simultaneously detected by near-infrared spectroscopy (NIRS) before and after acetazolamide administration, were investigated. The rCBF (ml/min/100 g) increased significantly from 40.2167.65 to 56.24613.69 (p,0.001), and a significant increase in oxyhemoglobin (Oxy-Hb) of 13.9% (p50.0022) and total hemoglobin (Total-Hb) of 5.7% (0.0047) along with a significant decrease in deoxyhemoglobin (Deoxy-Hb) of 8.9% (p50.0414) were observed concomitantly. Thus, the Oxy-Hb/Total-Hb ratio (%Oxy-Hb) rose significantly from 67.2669.82% to 72.98 68.09% (p50.0022). Examination of the relationships between individual parameters showed that the percentage changes in rCBF and Oxy-Hb were significantly correlated (r50.758, p50.011). The percentage changes in rCBF and %Oxy-Hb were also correlated significantly (r50.740, p50.014). In conclusion, this evidence suggested that NIRS is able to detect relative changes in cerebral hemodynamics and reflect luxury perfusion induced by acetazolamide. © 1999 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(99)00904-1]