The complex link between immunization against childhood diseases and allergy.

Vaccines can be at the origin of allergic manifestations in susceptible children. Such manifestations include: immediate-type hypersensitivity (anaphylactic shock, rash or angioedema) within 1 h after the injection; semi-late hypersensitivity (local inflammatory lesion such as the Arthus phenomenon) a few hours after the injection; and delayed-type hypersensitivity (abscess or eczema at the site of the injection). Furthermore, early-life vaccinations have been implicated in the modulation of the immune system as they could promote the development of allergy by avoiding infections. However, most population-based studies have not found an increased risk of allergies in vaccinated children. Due to methodological problems in conducting the studies, further investigations are needed to better understand the phenomenon.