Monte Carlo Analysis of a Subcutaneous Absorption Insulin Glargine Model: Variability in Plasma Insulin Concentrations

Absorption kinetics of long acting insulin such as Glargine often shows significant intra and inter-individual variability. To add this variability to the pharmacokinetics model of Glargine, ranges of variation for Glargine model parameters were introduced into 1000 Monte Carlo simulations. This assessment and analysis portray the likely intra-individual and inter-individual variability that could be expected clinically. The Monte Carlo analysis thus defines a range and distribution of identified and validated model parameter variations to consider in designing a glycaemic control protocol using Glargine.