Imidazolidin-2-one derivatives 1,3-disubstituted as inhibitors of CYP 17

A compound of Formula (Ia) or (Ib) wherein: n is 1, 2, or 3; R53 is (i) phenyl optionally substituted with 1 to 2 substituents each independently selected from fluoro, chloro, methyl, methoxy, trifluoromethyl, difluoromethyl, or cyano; (Ii) a biphenyl; (Iii) a fused phenyl selected from naphthalene-2-yl, quinolin-6-yl, 3,4-dihydro-2-oxo-quinolin-6-yl, benzo [b] -thiophene-5-yl, benzo [d] isoxazol-5-yl, 1H-indazole-5-yl benzothiazol-6-yl 6-1H-indazol-6-yl, 1,2-dihydro-3-oxoindazol-, indan-5-yl, 1H- benzotriazol-5-yl, benzofuran-5-2,3-dihydrobenzo dioxin-6-yl benzofuran-5-yl [1,4], 2,3-dihydro-, or benzo [1,3] dioxol -5-yl wherein said fused phenyl is optionally substituted with 1 to 2 substituents each independently selected from chloro, fluoro, methyl, ethyl, difluoromethyl, trifluoromethyl, cyclopropyl, cyano, or amino; (Iv) a 5- to 6-membered selected isothiazole-4-yl-3-thiophen-yl, thiophen-2-yl, or pyridin-4- yl, wherein said isothiazole-4-yl, which thiophene-2 yl, thiophen-said 3-yl, and said pyridin-4-yl are optionally substituted by fluoro, chloro, methyl, trifluoromethyl, difluoromethyl, or methoxy; or (v) a fused heteroaryl selected from thieno [3,2-c] pyridin-2-yl, thieno [3,2-c] pyridin-3-yl, thieno [3,2-c] pyridin-2- yl , imidazo [1,2-a] pyridin-7-yl, or benzo [b] thiophen-2-yl, wherein said fused heteroaryl is optionally substituted with 1 to 2 substituents each independently selected from fluoro, chloro, methyl, difluoromethyl , trifluoromethyl, cyclopropyl, or amino; R54 is (C1-C4) haloalkyl (C1-C4) alkyl, or -CH2OH; p is 0, 1, 2, or 3; q is 0, 1 or 2; R50, R51 and R52 25 are each independently H, halo, -OH, -CN, (C1-C4) halo-alkyl (C1-C4) alkyl, hydroxy (C1-C4) alkyl, - (CH2) r -O (C1-C4), - (CH2) r-CH (O (C1-C4)) 2, -NH2, -NH (C1-C4), - N ((C1-C4) -alkyl) 2, -NHC (O) (C1-C4), -C (O) NH2, -C (O) -NH (C1-C4), -C (O) -N ((C1-C4) -alkyl) 2, or - C (O) - O- (C1-C4); r is 0, 1 or 2; with the proviso that when R50, R51, R52 and R53 are H and is phenyl, R53 is unsubstituted or 30 substituted with halogen or CF3; or a pharmaceutically acceptable salt thereof.