Serological diagnosis of early liver cirrhosis

Objective To study the role of serum markers in diagnosing early liver cirrhosis.Methods Liver biopsy and serum fibrotic markers including hyaline acid (HA),collagen Ⅳ,laminin(LN),procollagen III peptide(PⅢP) were examined in 102 patients with chronic hepatitis type B.The role of these serum markers in diagnosing early cirrhosis was evaluated in comparison with histological standard.Results HA and collegan Ⅳ were increased with the aggravation of fibrotic degree,and the difference between S4 and S1 S3 groups was significant.The cut off value of HA and collagen Ⅳ by ROC analysis had the sensitivity and specificity of 70%-80% in diagnosing liver cirrhosis.Conclusion HA and collegan Ⅳ are useful in diagnosis of early liver cirrhosis.Combined examinations including discriminant analysis are no more valuable than any of these two serum markers.