Alkaloids from leaves and root bark ofErvatamia hirta

Abstract During chemical investigation of the leaves and root bark of Ervatamia hirta , 33 alkaloids were isolated. Seven are new: six are the ‘monomeric’ alkaloids ( E ) 16- epi -normacusine B , ( E ) 16- epi -affinisine, O -acetyl-16- epi -affinisine, affinisine- N (4)-oxide, dehydro-16- epi -affinisine, norfluorocurarine- N (4)-oxide, and the seventh is the bisindole 16-decarbomethoxyvoacamine-pseudoindoxyl. The known alkaloids are: ( E ) 16- epi -isositsirikine, β-yohimbine, yohimbine, 19,20-dehydro-β-yohimbine, β-yohimbine-pseudoindoxyl, isositsirikine, 19,20-dihydroisositsirikine, β-yohimbine-oxindole, normacusine B , affinisine, vobasine, dregamine, tabernaemontanine, norfluorocurarine, 12-hydroxynorfluorocurarine, apparicine, 3,14-dihydroellipticine, antirhine, voacristine, ibogaine, i☐ygaine, i☐ygaine-hydroxyindolenine, iboluteine, 4′,17,(17β)-dihydrotchibangensine, 16-decarbomethoxyvoacamine and 19,20-dihydro-16-decarbomethoxyvoacamine. Structural elucidation of the new alkaloids is based on spectral data and chemical correlations.