Correlation of VEGF expression with microvessel and microlymphatic density in sinonasal squamous cell carcinoma

Objective:To study the expression of VEGF in sinonasal squamous cell carcinoma and its correlations with microvessel density(MVD),microlymphatic vessel density(MLVD).Method:The expression of VEGF,MVD and MLVD in 41cases of sinonasal squamous cell carcinoma were detected by immunohistchemical technique.Result:In the sinonasal squamous cell carcinoma,the positive rate of VEGF was 82.9%(34/41).The over expression of VEGF was related with tumor invation,histological grading and lymphatic metastasis(P0.05).The MVD of cases with positive VEGF expression was significantly higher than those without VEGF expression(P0.05),but was not statistical difference in MLVD(P0.05).Conclusion:VEGF may participate in the metastasis of sinonasal squamous cell carcinoma through promoting vascularization in the tumors,but not promoting MLVD.