Synthesis and Biological Evaluation of Some New Coumarin Derivatives

Abstract: Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c][1]benzopyran-6-one derivatives ( 5-7 and 10 ) could be obtained via reaction of 2-amino-4-( p -bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c][1]benzopyran-5-ones ( 3a,b ) with a variety of reagents. Alkylation of( 3b ) with either 2-furoyl chloride or chloroacetyl chloride gave the 2- N -substituted derivatives ( 9a,b ). Benzofurano[3,2-b]4H-pyran derivative (12 ) was also prepared. The antimicrobial activity of the prepared compounds was tested. Keywords Pyrano[3,2: -c][1]benzopyran ; pyrimidino[5`,4`-6,5]-; pyrrolo[3`,2`-5,6]4H-pyrano[3,2-c][1]benzopyran-6-one; antimicrobial activities. Introduction Coumarins are nowadays an important group of organic compounds that are used as bactericides [1-3], fungicides [4], anti-inflammatory [5], anticoagulant [6] and antitumour agents [7,8]. These pharmacological properties of coumarins aroused our interest in synthesizing several new compounds featuring different heterocyclic rings fused onto the coumarin moiety with the aim of obtaining more potent pharmacologically active compounds.