An Alternate Enantiospecific Synthesis of Methyl (S)-7-tert- Butoxycarbonyl-2,3,4,5- tetrahydro-4-methyl-3-oxo-1H-1,4- benzodiazepine-2-acetate.

Abstract An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate ( 5 ) is reported. The key step, which involves an intermolecular displacement of the activated aryl fluoride ( 9 ) by L-aspartic acid β-methyl ester, proceeds without racemization.