Transforming growth factor β1, matrix metalloproteinase-2 and its tissue inhibitor in patients with pseudoexfoliation glaucoma/syndrome
2012
Background/Aim. Transforming growth factor-b1 (TGF-b1), oxidative stress and
imbalance between matrix metalloproteinases (MMPs) and their tissue
inhibitors (TIMPs) may play an important role in pathogenesis of
pseudoexfoliation syndrome/glaucoma (PEX Sy/Gl). The aim of the study was to
measure concentrations of TGF- b1, MMP-2, TIMP-2 in the aqueous humor in the
examined group, as well as to compare the biochemical findings with the
following clinical parameters: degree of chamber angle pigmantation, presence
of pseudoexfoliation and the value of intraocular pressure (IOP). Methods.
Aqueous samples from 30 patients with cataract, 30 patients with PEX Sy, 36
patients with PEX Gl, and 42 patients with primary open-angle glaucoma (POAG)
were collected during phacoemulsification cataract surgery. TGF b1, MMP-2,
TIMP-2 Fluotokine Multi Analyze Profiling kits and Luminex technology were
used to simultaneously measure TGF b1, MMP-2 and TIMP-2. Results. TGF- β1,
MMP-2, TIMP-2 were detected in human aqueous from all the groups with the
highest level in the group with PEX Gl. Statistically, a significant
correlation between the levels of TGF b1, MMP-2, TIMP-2 in the aqueous humor
of the patients with PEX Gl and the IOP value was confirmed (p < 0.05). In
this group, the positive correlations between the TGF b1 concentration in the
aqueous humor and the presence of pseudoexfoliation (p < 0.01), on the one
hand, and between the TIMP-2 level and the presence of pseudoexfoliation (p <
0.05), on the other, were reported. A statistically significant positive
correlation of TGF-b1 and MMP-2, and the degree of chamber angle pigmentation
in the PEX Gl group was confirmed (p < 0.05). In the POAG group, TIMP-2
values were in a negative correlation with the degree of pigmentation (p <
0.05), and the IOP value (p < 0.05). Conclusion. TGF b1 and MMP-2 affect the
degree of chamber angle pigmentation and the degree of pseudoexfoliation in
patients with pseudoexfoliative glaucoma.
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