Luteinizing Hormone Releasing Hormone Analogue in Treatment of Hypergonadotrophic Amenorrhoea

Summary. The effect of a luteinizing hormone releasing hormone analogue (HOE 766) was studied in four patients with hypergonadotrophic amenorrhoea (resistant ovary syndrome). After an initial phase of stimulation, there was a uniform and sustained suppression of gonadotrophin concentrations in all the patients during the 20–24 days of treatment, presumably due to down-regulation of the pituitary receptors. One patient ovulated after stopping treatment.