BLOOD-BRAIN BARRIER FRACT AL ULTRASTRUCTURE UNDER CONTINUOUS, RHYTHMIC AND CHAOTIC HYPOTHERMIA

Using radioisotope method for determining the neurotransmitters transport, electron microscopy and fractal morphometry the functional architectonics of neuro-glial-endothelial complexes of rat brain was studied. It is shown that under the continuous hypothermic effects the fractal dimen sion (D) of brain capillary endothelium increased monotonically up to D ~ 1,5. Under periodic effects of hypothermia ��D has a definite rhythmic, pattern (the antipersistent periods lie between the persistent), which indicates the increase in plasticity, but the preservation of the structure stability. Under cooling the blood-brain barrier permeability (especially under the chaotic regime) for norepinephrine (D ~ 1,3) and acetylcholine (D ~ 1,7) is increase, which can be used in cryomedicine.