Folate Supplementation for Methotrexate Therapy in Patients With Rheumatoid Arthritis

ObjectiveTo review the evidence for benefits and harms of folate (folic acid or folinic acid) supplementation on methotrexate (MTX) treatment for rheumatoid arthritis (RA), to assess whether or not folate supplementation would reduce MTX toxicity or reduce MTX benefits, and to decide whether a highe