Concentrations sériques jugulaire et artérielle de la protéine S100B chez les patients victimes d'un traumatisme crânien grave Jugular venous and arterial concentrations of serum S100B protein in patients with severe head injury

It is important for physicians in intensive care units to be able to predict the presence and severity of central nervous system injury in patients with severe head injury (SHI). The extent of S100B elevation has been found to be useful in predicting clinical outcome after brain injury. However, only two studies were realized with jugular venous blood samples. The purpose of our study is to compare the interest between jugular venous and arterial concentra- tions evaluation of serum S100B protein in patients with SHI. We recruited 17 patients with a SHI, admitted to the intensive care unit. Paired arterial and jugu- lar venous samples were taken at kinetically after injury. S100B median was 0.16 g/L in arterial and 0.25 g/L in jugular. This arterio-jugular difference is significant. However, there was any significant arterio-jugular difference in the patients group showing an unfavourable outcome or for the earlier samples (earlier than 24h). We observed there was no significant decrease of S100B