Research progress of CD73 in diseases

CD73, also known as 5'-nucleotidase, is a ubiquitous glycoprotein linked to the cell membrane via GPI. CD73 has hydrolase activity, which can degrade adenosine 5'-phosphate into adenosine, and then exert the effects of angiogenesis, paracrine and immunosuppression through the interaction of adenosine and various adenosine receptor subtypes. In addition, CD73 can play a non-enzymatic role in mediating cell-to-cell binding and signal transduction. CD73 is associated with many diseases, such as tumors, myocardial injury, brain injury, diabetes mellitus, Toxoplasma invasion, systemic lupus erythematosus, organ transplantation and so on. Adenosine and adenosine receptors produced by CD73 and its hydrolysis affect the physiological and pathological processes of the body. This article reviews the basic and clinical research of CD73 in recent years, and the relationship between basic research and clinical application of CD73. Key words: CD73; Tumor; Myocardial injury; Brain injury; Toxoplasma infection;  Organ transplantation