Abstract 16775: Glycemic Variability Correlated With Vascular Stiffness and LV Filling Pressure at 1 Year After Onset of First ST-segment Elevation Myocardial Infarction: MRI and Tissue Doppler Analysis

Introduction: Glycemic Variability (GV) may play an important role in patients with ST-segment elevation myocardial infarction (STEMI). But the clinical significance of GV is not fully understood in patients with a first STEMI. Methods: Consecutive 148 patients with a first STEMI (64±12 years, 88% male, max CPK=2964 IU/L, LAD 80/LCX 15/RCA 53), who had undergone reperfusion therapy within 12 hours after onset were enrolled. We analyzed GV by a continuous glucose monitoring system (CGM: iPRO2, Medtronic) at 2 weeks and mean amplitude of glycemic excursions (MAGE) as the parameter of GV. The infarct size was evaluated by using late-gadolinium enhancement (CMR-LGE) at 1 week. The cardio-ankle vascular stiffness index (CAVI) is not affected by blood pressure at the time of examination, thereby we examined CAVI at 2 weeks as the parameter of arterial stiffness. We assessed cardiac function measured by echocardiography and BNP at 12 months from discharge. E/e’ was measured as the marker of left ventricular (LV) filling pressure. Results: MAGE had significant relationship with CAVI (r=0.177; p Conclusions: MAGE correlated with arterial stiffness and predicted elevated LV filling pressure at 12 months in patients with a first STEMI.