FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIANANEMIA PADA PEMAKAIAN ZIDOVUDIN PASIENHIV/AIDS
2015
Background: The administration of Zidovudine (ZDV) has an important role in
decreasing the number of mortality on HIV/AIDS patients. Nevertheless,
Zidovudine is known to make a side effect of anaemia. The incidence of anaemia
can be influenced by several factors, e.g. age, sex, duration of therapy, CD4
count, and ALT count.
Aims: This research aims to determine factors influencing incidence of anaemia
on HIV/AIDS patients with Zidovudine treatment in Dr. Kariadi General Hospital
Semarang and see the correlation between those determinant factors to the
incidence of anaemia.
Methods: This research is an analytic observational with cohort-retrospective
method used. There were 70 HIV/AIDS patients with Zidovudine, divided into two
groups: 35 patients belonged to case group, while the other 35 patients belonged
to control group. The data was taken from medical records and analyzed by Chisquare
and Fischer test.
Results: Age did not have any correlation to incidence of anaemia (p=0.075). Sex
was a contributing factor to incidence of anaemia (p=0.027) in which female
patients were more susceptible to anaemia. Duration of therapy was a
contributing factor to incidence of anaemia (p=0.000) particularly patients with
less than 12 months of therapy. CD4 count did not have any correlation to
incidence of anaemia (p=0.055). ALT count did not have any correlation to
incidence of anaemia (p=1.000).
Conclusion: The administration of Zidovudine corresponds to the incidence of
anaemia with sex and duration of therapy as the influencing factors on HIV/AIDS
patients in Dr. Kariadi General Hospital Semarang.
Keywords: HIV/AIDS, Zidovudine, Anaemia
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