On the synthesis of (S)-α-methylaspartic acid by diastereoselective alkylation of a chiral 2-cyanopropanoate

Abstract A novel and efficient procedure for the synthesis of optically pure α-methylaspartic acid, based on the diastereoselective alkylation of (1 S ,2 R ,4 R )-10-(dicyclohexylsulfamoyl)isobornyl 2-cyanopropanoate with α-halocarbonyl compounds, is described.