Newly identified lectin from Photorhabdus asymbiotica and itsstructure-functional study
2014
Our project is focused on study of a new lectin from the
Photorabdus asymbiotica bacterium (PHL). Photorabdus
asymbiotica belongs to the Photorabdus genus together with
Photorabdus luminiscens and Photorabdus temperata. The latter 2
species are characterized as strictly virulent insect
pathogens. In contrast, P. asymbiotica is also a human
pathogen, which causes locally invasive soft tissue and
disseminated bacterimic infections. We have identified a new
putative lectin in the P. asymbiotica genome with the predicted
structure similarity to the lectins from so-called AAL family,
which are specific for fucosylated oligosaccharide. The AAL
family contains AAL from Aleuria aurantia which inhibits a
repair of epithelia or the RSL lectin from Ralstonia
solanaccearum predicted as one of the key virulent factors of
this plant pathogen.
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