Fibrinolytic Activity in Laparoscopic Cholecystectomy

ABSTRACT The aim of this study was to examine the fibrinolytic activity in laparoscopic cholecystectomy (LC) to determine whether changes occur that might indicate a greater risk of thrombosis. The study was carried out in 20 patients who had undergone laparoscopic surgery for cholelithiasis without complications. The average age was 59.4 years (34–77 years). Seventy-five percent were women. The mean operating time was 70 minutes (35–120 minutes). Pneumoperitoneum at 14 mm Hg was maintained in all patients, and they were in 30° reverse Trendelenburg position. Postoperative mobilization was obtained before 24 hours, and patients were discharged 48 hours after surgery. The control group was composed of 12 patients, evenly distributed by age, sex, and length of surgery, who had undergone Bassini herniorraphy without complications or relapses. The following hemostatic parameters were studied: plasma fibrinolitic activity (PFA), euglobulin fibrinolytic activity (EFA), tissue-type plasminogen activator (t-PA), ...