NSCLC as a chaperonopathology: diagnostic and prognostic significance of HSPB5.

Methods ELISA was applied to determine the plasma levels of HspB5 in 45 patients, operated on for NSCLC, 38 high risk COPD patients and 45 age and sex-matched healthy volunteers. The pTNM of NSCLC patients was defined according to the 7th revision of TNM staging system. All operated on patients were followed up either their death or up to 5 years. ROC analysis was used to characterize the diagnostic role of HspB5. The one and fiveyear survival rates were defined by Kaplan-Maier.