FORMULATION AND EVALUATION OF MATRIX FLOATING TABLETS OF OFLOXACIN AND TINIDAZOLE COMBINATION

Floating matrix tablets of Ofloxacin and tinidazole were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Ofloxacin chosen as a choice of drug because it is well absorbed from stomach and Tinidazole is well absorbed in stomach and upper part of small intestine. Preformulation studies were carried out to optimize the required quantity for HPMC (K4M). Xanthan gum (5%), carbopol 934P (10%) was used in Fourier transform Infrared spectroscopy confirmed that absence of any drug/polymers/excipients interactions. Formulations were prepared using HPMC K50, HPMC K100, HPMC K4, Xanthan gum with carbopol 934P at Different Ratios. F12 Formulations showed in-vitro buoyancy 11 hrs. The concentration of HPMC K4 was increased to control the release of drug from the dosage form for F9 to F12 batches; the concentration was increased for Xanthan gum to increase the binding nature. The cumulative % drug release of F12 formulation was found to be Ofloxacin (95.8%), Tinidazole (92.8%) at the end of 11 th hr. The formulation containing HPMC k4m and Xanthan gum (1:1) showed better results compared to other formulated batches. Further Stability studies and IVIVC correlation studies can be performed to ensure the efficacy of the formulated floating tablets