EFFICACY OF STATINS AND FIBRATES IN ALTERING THE LIPID PROFILE IN HYPERTENSIVE PATIENTS

Lipid lowering drugs have become most powerful Pharmacological strategies in treatment of cardiovascular diseases. In our study of 100 patients having an age range from 35 to 65 years were enrolled. The antihypertensive used were Angiotensin Converting Enzym Inhibitors (Lisinopril 10mg / day) & Calcium channel blockers (Amdolipine 5 mg/ day). Lipid profile was done at base line and then repeated after 12 and 24 weeks Group A received Fenofibrate 40 mg/day and Group B received Atorvastatin 20 mg/day, group A showed fall in LDL-C, TG & TC and the percentage fall was 18%,35%, and 20% respectively, whereas the HDL-C levels were elevated by 16%. The fall was rapid during the 1 st three months. And then slow in the last three months. The patients of group B on atorvastatin showed a fall of 35%, 28% and 26% in the levels of LDL-C, TG and TC respectively and the rise in HDL-C was 8%. Our study showed a greater effect of fenofibrate in lowering TGs & raising HDL-C whereas Atorvastatin was more effective in lowering LDL-C and moderately lowered TGs.