Etiological Study of Fungal Infection in Pediatric Patients

Objective To investigate the characteristics of pathogen distribution and drug resistance in pediatric fungal infection.Methods The fungi were identified by VITEK2-Compact verification and the drug sensitive experiments were done by ATBTM FUNGUS 3 trial.Results There were 558 fungal strains in all samples.The major infection site was respiratory tract(299 cases,53.58%);infection rates in intestinal tract, wound, urinary tract and blood were 28.14%, 6.27%, 4.66% and 3.76%, respectively.The most common infection pathogen was Candida albicans(367strains,65.77%), infection rates with Candida tropicalis, Candida glabrata, Candida parapsilosis, Candida kruse and Candida guilliermondii were 15.28% , 5.02% , 4.48% , 3.41% and 2.69% , respectively.These anti-fungus medicine resistance of 558 fungal strains to amphotenicin B(AMB), 5-flucytosine(5FC), fluconazole(FCA), itraconazole(IRT) and voriconazole(VRC) were 8.78%, 4.84%, 10.54%, 1.36% and 0.85%, respectively.Conclusion Candida albicans was the most important pathogen in pediatric fungal infection.The key of successful treatment was maintaining high alertness and identifying mycosis at an early stage.