Effects of remifentanil on N-methyl-D-aspartate receptor : An electrophysiologic study in rat spinal cord

Background:Remifentanil hydrochloride contained in Ultiva® (GlaxoSmithKline, Genval, Belgium) has been incriminated in difficult postoperative pain management, promotion of hyperalgesia, and direct N-methyl-d-aspartate (NMDA) receptor activation, but the involved mechanisms have remained unclear. In