Gastric Parietal Cell Regeneration by Nano-Scaffolding in Hypochlorhydria and Achlorhydria Treatment

Hypochlorhydria and achlorhydria are conditions in which the production of hydrochloric acid (HCl) in the stomach is reduced or completely absent, mostly because of an underlying medical condition, such as gastric cancer. Subtotal or total gastrectomy is commonly performed in patients who suffer from gastric cancer. But, advances in the field of tissue engineering allowed the fabrication and regeneration of many tissues, therefore supporting the idea that hypochlorhydria and achlorhydria could be treated in that manner, especially by nano-scaffolding, the process of tissue regrowing using polymer fibres at a nanoscale. The main goal of this article is to present theoretical premises of tissue engineering and combine findings from multiple studies which, when formulated in a form composed of four steps (preparation of the polymeric biodegradable nano-scaffold, preparation and multiplication of gastric cells, integration of gastric cells into a nano-scaffold and transplantation of the nano-scaffolded tissue into the interior of the stomach), followed by the vascularisation process and biodegradation, gives a novel theoretical possibility when it comes to managing these patients. We gathered scientific articles, professional literature and electronic books by researching databases, such as PubMed and Google Scholar, which were used as main sources of information when creating this article. Additionally, we used Medical Subject Headings (MeSH) in order to make a more precise search. Further research is needed for this procedure to resuscitate and make treatment of hypochlorhydria and achlorhydria easier and more efficient.