Thermogravimetric investigations of gel shampoo with minoxidil

On the department of technology of medications Zaporizhzhia State Medical University as a result of complex biopharmaceutical, physico-chemical and microbiological investigations the shampoo-gel with minoxidil 1% for the therapy and prevention of the androgenous alopecia on the complex base of anion-active, nonionic and amphoteric surfactants providing with a high foaming ability was developed. The aim of this work is study of thermal treatment effects of gel shampoo with diltiazem over the temperature range of technological process of manufacturing for this dosage form. As the objects for the thermogravimetric investigations minoxidil, minoxidil shampoo on the gel base and the base were used. Thermogravimetric analysis was carried out on the derivatograph Shimadzu DTG-60 (Japan) with the platinum and platinum-rhodium thermopair with samples heating in aluminium crucibles from 25 to 200 oС. According to thermogravimetric experimental data minoxidil is a thermal stable substance from 26 to 240 oС. Thermal effects on the derivatogramm of minoxidil gel shampoo coincide with thermal effects of the base components and that fact indicates lack of the chemical interact between active substance and excipients in semisolid dosage form. Preparation of the gel shampoo with minoxidil 1% in the temperature range using in manufacturing technological process for creams on the emulsion base (50‒80 oС) doesn’t lead to destruction of the components of the present dosage form.