Effect of medicine mulberry different extracts on type 2 diabetic mellitus

Objective To investigate the effect of medicine mulberry different extracts on type 2 diabetic mellitus(T2DM).Methods T2DM model rats were established by intraperitoneal injection streptozotocin(STZ)and high sugar and high lipid diet.Model rats were divided into model,baitangping control,medicine mulberry alcohol extract(20 mg/kg)and water extract(20 mg/kg)groups and normal control group was selected.Glucose,fructosamine,total cholesterol(TC),triglyceride(TG),low density lipid protein cholesterol(LDL-C)and high density lipid protein cholesterol(HDL-C)were detected after 4 weeks.Hepatic glycogen,superoxide dismutase(SOD),malondialdehyde(MDA)in liver tissue were measured.Results Compared with normal control group,glucose,fructosamine,MDA,TC,TG,LDL-C were increased in model group(P0.01),and hepatic glycogen,HDL-C and SOD were decreased(P0.05).Compared with model group,medicine mulberry could improve above indexes(P0.05).Conclusions Different extracts of medicine mulberry has therapeutic effect on T2DM by decreasing glucose,increasing anti-oxidant ability.