Dilated cardiomyopathy: the complexity of a diverse genetic architecture

The underlying genetics of dilated cardiomyopathy are complex, and the condition can be caused by mutations in any one of more than 30 genes. In this Review, Hershberger and colleagues assess the diverse genomics of this condition and how they might intersect with those of the hypertrophic and arrhythmogenic right ventricular forms of cardiomyopathy.