Clindamycin phosphate methanol - aqueous solvent and a method for preparing crystalline compound

The present invention provides a clindamycin phosphate methanol - aqueous solvent and a preparation method of the compound crystal; clindamycin phosphate crystals methanol - aqueous solvent compound as crystals. Clindamycin phosphate 1 molecule of methanol - water contained in the solvate crystals clindamycin phosphate molecule, one molecule of methanol and 2 molecules of water. The crude clindamycin phosphate was dissolved in deionized water and a mixed solvent of methanol, and the initial concentration of clindamycin phosphate 0.09-0.12g / mL, the solution was heated with stirring until dissolved, hot filtered, the filtrate was put evaporate slowly at room temperature for five to seven days time environment, to appear as a white crystalline solid was filtered to give clindamycin phosphate methanol - aqueous solvent compound as crystals. Good stability of the crystal, normal temperature clindamycin phosphate methanol - water solvate crystals placed in a 10 day 30 ℃, respectively fifth and 10th day sample X- ray powder diffraction, the crystal is determined stabilize the situation.