New pyrimidine inhibitors of human adenovirus replication

FIELD: pharmacology. SUBSTANCE: invention relates to new 5-aminouracil derivatives containing 4-(phenoxy) benzyl or ω-(phenoxy)alkyl substituent in the N 1 position, corresponding to the general structural formula (I). Compounds represent a new class of anti-adenoviral agents of a non-nucleoside nature. In the general formula (I), X = CH or N; Y=(CH 2 ) 2 , (CH 2 ) 3 , (CH 2 ) 4 or C 6 H 4 ; R1= H, R2= C 6 H or 3,5-Cl 2 C 6 H 3 ; R 1 +R 2 = morpholino; R 3 =H, F or Cl. EFFECT: compounds have a selective antiviral effect against human adenoviruses and can be used for treatment of adenoviral infections. 1 dwg, 3 tbl, 11 ex