Expression of Rictor and mTOR in colorectal cancer and their clinical significance

To explore the expression of Rictor and mTOR in the colorectal cancer and their clinical significance.The expression levels of Rictor and mTOR in HCT116, SW480, LoVo and HCoEpiC cells were detected by indirect immunofluorescence and Western blotting. Sixty-two paraffin-embedded surgical specimens of colorectal cancer tissue and adjacent tissues were examined for Rictor expression using immunohistochemistry. The association of the expression levels of Rictor protein with the clinicopathologic features and the overall survival of the patients was analyzed.The expression level of Rictor was significantly higher in colorectal cancer tissues than in the adjacent tissues (P 0.05). Patients with Rictor expression had a lower overall survival rate than those without Rictor expression.Rictor overexpression is associated with the carcinogenesis and progression of colorectal cancer and can be an independent indicator for evaluating the prognosis of colorectal cancer patients.