New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs

Abstract An efficient and regioselective procedure for the synthesis of a series of alkyl(aryl/heteroaryl) substituted 3-trifluoromethyl-1 H -1-phenylpyrazoles and alkyl 3-carboxylate analogs, from the cyclocondensation reactions of 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones [CX 3 C(O)CR 2 =CR 1 (OMe/OEt), where R 1 = H, Me, Ph, 2-Furyl; R 2 = H; R 1 -R 2 = -C 4 H 8 - and X = F, Cl] and 1-phenylsemicarbazide in an acidified alcoholic medium (R 3 OH/H 2 SO 4 ), where R 3 = Me, Et, Pr i was successfully applied and is described here in detail.