Drug interaction. An important consideration for rational pediatric therapy.

In its broadest sense, drug interaction may refer not only to the reaction between two or more therapeutic agents, but also to the interplay between an administered agent and a component of the host. Thus we may have drug-drug and drug-food interactions, and drug interactions with a particular clinical condition. The latter is particularly true in the rapidly growing infant or child, where host factors may result in qualitative as well as quantitative differences in drug interactions.