HAb18G/CD147 Functions in Invasion and Metastasis of Hepatocellular Carcinoma

CD147 molecule is reported to be correlated with the malignancy of some cancers; however, it remains unclear whether it is involved in the progression of hepatocellular carcinoma (HCC). Here, we investigated the function of HAb18G/CD147, a member of CD147 family, and its antibodies, HAb18 and LICARTIN, in HCC invasion and metastasis. We observed that HAb18G/CD147 gene silence in HCC cells significantly decreased the secretion of matrix metalloproteinase (MMP) and the invasive potential of HCC cells ( P P 131 I-labeled HAb18 F(ab′) 2 (LICARTIN), however, significantly inhibited the in vitro growth of HCC cells ( P