Applicability of Ultra Performance Convergence Chromatography, a New Generation of Supercritical Fluid Chromatography, for the Analysis of Pesticide Residues

Monitoring and controlling wide variety of pesticide residues is a crucial challenge of food safety. In our study ultra-performance convergent chromatography (UPC 2 ), as the new generation of supercritical fluid chromatography coupled with ESI-MS/MS system was applied to separate a set of pesticides to investigate their chromatographic behavior under various UPC 2 conditions. 30 components were selected representing the GC and LC measurable components. Capacity factors obtained from LC and GC runs UPC 2 -PDA were compared. Based on our data UPC 2 should be considered as an alternative chromatographic approach with separation mechanisms not yet fully characterized. Interestingly the type of mobile phase modifier influences the ionization in an ESI-MS system.