ГОРМОНАЛЬНАЯ РЕЗИСТЕНТНОСТЬ ПРИ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЯХ КИШЕЧНИКА

Systemic glucocorticosteroids are widely used in the treatment of inflammatory bowel disease, and despite the introduction of new anti-inflammatory drugs, remain the first-line therapy for induction of remission in moderate and severe ulcerative colitis and Crohn's disease. However, in some patients steroid resistance is observed when glucocorticosteroids are not effective enough. The paper gives a detailed discussion of the criteria of steroid resistance, possible mechanisms of it's development, including secondary resistance resulting from complications of ulcer-ative colitis and Crohn's disease and associated opportunistic infections. Special attention is paid to the modern treatment of steroid-refractory inflammatory bowel disease.