Синтез анионных производныхмио-инозита и других полиолов и исследование их антивирусной активности

In recent years, various polyanionic substances capable of effectively inhibiting virus penetration into cells have been studied in the search for new effective antiviral preparations. In this study, phosphate and sulfate derivatives of 2,3,4,5-tetra-O-benzyl-D,L-iditol, 1,12-dodecanediol, and a dimeric inositol analog containing phospholipids were synthesized. The dimeric compound, in which two myo-inositol cyclitol rings are bound by one hydrophobic fragment, was obtained using the H-phosphonate method. The results of testing for the antiviral properties of some compounds showed no activity against rhinoviruses. Bis-sulphate of 2,3,4,5-tetra-O-benzyl-D,L-iditol inhibited Coxsackie virus and exhibited the most pronounced cytotoxicity. Bis-sulphate of 1,12-dodecandiol was found to be inactive against all viruses. Bis-phosphate of 2,3,4,5-tetra-O-benzyl-D,L-iditol and monosulphate of 1,12-dodecandiol were effective against herpes simplex virus of types 1 and 2.