The Longitudinal Relationship Between Physical Activity and Joint Space Narrowing: 48-Month Follow-Up Data from the Osteoarthritis Initiative.

Objective To determine whether amount of physical activity (PA) is a determinant of joint space narrowing (JSN) worsening over 48-months in participants with knee osteoarthritis (OA). Methods Data were obtained from the Osteoarthritis Initiative. PA, measured using the Physical Activity Scale for the Elderly (PASE), was defined as the mean value of the annual measurements conducted prior to development of worsening JSN. Worsening JSN was defined as at least a partial grade increase in OARSI JSN score over 48 months, in comparison with baseline. Restricted cubic spline (RCS) function was used to group participants based on the linear association between PA and JSN worsening. A pooled logistic regression model was used to evaluate the association between PA and JSN worsening adjusted for confounders. Results 2,167 participants were included. In total, 625 (28.8%) participants had JSN worsening over 48 months. Compared with PASE score of 140-180, PASE scores of 100-140 and >220 associated with an increased risk of JSN worsening in men with OR (95% CI) of 1.73 (1.07, 2.81) and 1.83 (1.14, 2.93) respectively. Similarly, in participants with Kellgren and Lawrence grade 2, compared with a PASE score of 140-180, PASE score of 220 were associated with increased risks of JSN worsening, with OR (95% CIs) of 1.69 (1.13, 2.54) and 1.64 (1.05, 2.56) respectively. Conclusion Compared to moderate PA, higher or lower amounts of PA are associated with elevated risk for JSN worsening in men and in participants with KL grade 2 knees.