The immune-profile of mismatch repair deficient (dMMR) colorectal cancers (CRCs) differs according to primary tumor sidedness.

Roberto Moretto,Riccardo Giannini,Gemma Zucchelli,Mirella Giordano,Filippo Pietrantonio,Carlotta Antoniotti,Clara Ugolini,Federica Morano,Federica Marmorino,Elisa Sensi,Antonino Belfiore,Daniele Rossini,Cristiana Lupi,Gianluca Masi,Beatrice Borelli,Elena Ongaro,Alessandra Boccaccino,Alfredo Falcone,Gabriella Fontanini,Chiara Cremolini

The immune-profile of mismatch repair deficient (dMMR) colorectal cancers (CRCs) differs according to primary tumor sidedness.

2018

e15593Background: The high mutational load of dMMR CRCs elicits a considerable endogenous immune anti-tumor response, counterbalanced by immune inhibitory signals. We aimed at describing the immune...

Keywords:

Pathology
DNA mismatch repair
Primary tumor
Immune system
Cancer research
Medicine
Endogeny

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