Pretreatment serum levels of myeloid-derived suppressor cells (MDSC) are effective as a prognostic indicator in patients with breast cancer.

e14006 Background: A suppression of cell mediated immunity and malnutrition are commonly seen in patients with advanced cancer and it has been reported that chronic inflammation plays a key role in induction of these conditions. We have reported that MDSC: myeloid-derived suppressor cells, found as a new type of immune suppressor cells that is closely related to chronic inflammation, is increased in patients with various types of cancer including gastrointestinal, hepatopancreatic, breast, thyroid and ovarian cancers, and the levels of MDSC were closely related to systemic inflammation, immunosuppression and nutritional impairment. Especially in breast cancer, the levels of MDSC have been reported to decrease after the removal of the tumor and to increase with recurrence. Methods: Peripheral blood mononuclear cells (PBMC) were collected from 106 preoperative patients with breast cancer including 19 patients with stage I, 48 with stage II, 12 with stage III and 27 with stage IV diseases, and these cells we...