Assessing 2-month clinical prognosis in patients with solid tumors: Final results of PRONOPALL study.
2011
6047 Background: in 2008, we published in our results of a prognostic score defined by 4 factors (Karnofsky index, number of metastatic sites, serum albumin and LDH levels) in a population of 177 hospitalized patients in two hospitals (Assessing 2-Month Clinical Prognosis in Hospitalized Patients With Advanced Solid Tumors - Anne-Claire Barbot, Pascale Mussault, Pierre Ingrand and al. J Clin Oncol - vol 26, p 2358-2543. 2008.). Albumin cutoff is 33 g/l and LDH cutoff is 600 ui/l. This score defined 3 different patients populations: A: low score (0 to 3), B: intermediate score (4 to 7) and C : high score (8 to 10). The survival rates at 2 months were 92.2% ± 3.8 (population A), 42.7% ± 5.2 (population B) and 8.3% ± 4.6 (population C). Methods: In order to validate this score, we decided to start a second study in a large multicentric trial with a high proportion of out-patients. Results: Between October 2009 and October 2010, 302 patients were included from 16 institutions. Inclusion criteria: adults patie...
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