Simplified Structure of a New Model to Describe Urinary Excretion of Plutonium after Systemic, Liver or Pulmonary Contamination of Rats Associated with Ca-DTPA Treatments

Abstract Fritsch, P., Serandour, A. L., Gremy, O., Phan, G., Tsapis, N., Abram, M. C., Renault, D., Fattal, E., Benech, H., Deverre, J. R. and Poncy, J. L. Simplified Structure of a New Model toDescribe Urinary Excretion of Plutonium after Systemic, Liver or Pulmonary Contamination of Rats Associated with Ca-DTPA Treatments. Radiat. Res. 171, 674–686 (2009). This study validates, by targeted experiments, several modeling hypotheses for interpretation of urinary excretion of plutonium after Ca-DTPA treatments. Different formulations and doses of Ca-DTPA were administered to rats before or after systemic, liver or lung contamination with various chemical forms of plutonium. The biokinetics of plutonium was also characterized after i.v. injection of Pu-DTPA. Once formed, Pu-DTPA complexes are stable in most biological environments. Pu-DTPA present in circulating fluids is rapidly excreted in the urine, but 2–3% is retained, mainly in soft tissues, and is then excreted slowly in the urine after transfer to bl...