Synthesis of novel phase transfer catalysts derived from proline-mandelic acid/tartaric acid: their evaluation in enantioselective epoxidation and Darzen condensation
2019
Abstract
Herein, we have described the synthesis of novel chiral cyclic phase transfer catalysts (PTCs). These catalysts are synthesized from proline, mandelic acid and tartaric acid by using simple synthetic methods with competitive yields. These chiral cyclic phase transfer catalysts have been characterized by \(^{1}\)H NMR and \(^{13}\)C NMR spectroscopy, IR spectroscopy and elemental analysis. The effectiveness of these novel chiral cyclic phase transfer catalysts was evaluated by applying them in the enantioselective epoxide synthesis from \(\upalpha \), \(\upbeta \) unsaturated ketone (chalcone) and Darzens condensation. The obtained results show that the synthesized derivatives of proline, mandelic acid and tartaric acid are effectual as PTCs.
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