Ocular Developmental Lesions

Congenital anophthalmia is known as a rare congenital disease clinically. It is divided into two types according to the pathogenesis and organizational form: (1) primary anophthalmia: it is thought to be caused by the chromosome aberration in the early embryo (within 3 weeks), which results in underdevelopment of the optic vesicle or optic pit in the orbit. (2) Secondary anophthalmia: the optic vesicle is formed in the early embryo but degenerates due to some exogenous or endogenous causes, and thus the intact eyeball is failed to be formed.