원보 : Ferric Chloride로 유도된 렛트 경동맥 손상 및 혈전에 대한 수용성 엉겅퀴 잎 추출물의 혈행 개선 효과

The present study has been undertaken to investigate the effect of the extract of Cirsium japonicum var. ussuriense leaves (CLE) on blood circulation in a rat model of topical ferric chloride (FeCl3)-induced carotid artery damage. FeCl3 treatment seriously damaged the carotid artery such as the walls of the artery, blood flow and inflammation. However, CLE administration has ameliorated blood circulation and suppressed vessel inflammation. CLE administration also has ameliorated the FeCl3-induced artery tissue damage. Furthermore, CLE significantly suppressed the expression of adhesion molecules. These results suggest that CLE ameliorate blood circulation through suppress inflammatory mediator and adhesion molecule production.